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Diabetic retinopathy: more than meets the eye. Surv Ophthalmol. 2002;(suppl):S253 S262, with permission. Fundus photos courtesy of Jack Carlson, MD, Loma Linda, California. As with other microvascular complications of diabetes, the pathophysiology of DR appears to be multifactorial. Hyperglycemia results in increased adherence of white blood cells that traverse the tiny vascular channels of the retina. As the veins and arteries become obstructed, retinal blood flow is reduced, resulting in the abnormal vasculature appearance typically seen in patients with vood. Cotton-wool spots appear clinically when capillaries are completely occluded. As the leukocytes bind to the endothelium, inflammatory mediators are released that increase vascular permeability, producing hard exudates and edema. As hyperglycemia damages more small vessels, hypoxemia develops within affected areas of the retina.

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Love may be understood as a function to human beings together against menaces. The word love can have a variety of related but distinct meanings in different contexts, cultural differences in conceptualizing love thus doubly impede the establishment of a universal definition.

He is aided by Marion Ravenwood and Sallah, the Nazis are led by Joness archrival, a Nazi-sympathizing French archaeologist named RenĂ Belloq, and Arnold Toht, a sinister Gestapo agent. In the 1984 prequel, Indiana Jones and the Temple of Doom, set in 1935, Jones travels to India and attempts to free enslaved children and he is aided by Short Round, a young boy, and is accompanied by singer Willie Scott. The film was a movie of sorts, teaming Jones with his father.

The song was released as an single on June 16,2009. The single became one of Drakes most successful songs to date, the single also managed to peak at number one on both the US Top Ramp;BHip-Hop Songs and the Top Rap Songs charts, thus becoming Drakes first number one hit on both of these charts.]